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Bystander Adaptation in 3D

Posted By Administration, Wednesday, September 22, 2010
Updated: Monday, April 22, 2013

Welcome to the August 2010 issue of the Radiation Research Podcast. In this month’s issue, Vered Anzenberg’s News Minute focuses on educating immune cells with salmonella against melanoma.

 

Authors of the featured paper: Edouard Azzam (left photo), Massimo Pinto and Roger Howell (right photo).

The interview of the month is curated by Marjan Boerma, who spoke to the authors of the paper entitled Investigation of Adaptive Responses in Bystander Cells in 3D Cultures Containing Tritium-Labeled and Unlabeled Normal Human Fibroblasts.

 Attached Thumbnails:

Tags:  3D cell culture  adaptive responses  Bystander effects 

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Image-Guided Micro-Irradiation

Posted By Administration, Monday, August 23, 2010
Updated: Monday, April 22, 2013

Drs. Debabrata Saha and Timothy D. Solberg from the Department of Radiation Oncology, UT Southwestern Medical Center, Dallas, Texas, are interviewed about their work.Our conversation is based on their article published in the July issue of Radiation Research: An Orthotopic Lung Tumor Model for Image-Guided Microirradiation in Rats

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The Golden Age for Radiotherapy?

Posted By Administration, Wednesday, June 23, 2010
Updated: Monday, April 22, 2013

Drs. Devika B. Chithrani and David A. Jaffray from the Ontario Cancer Institute, University Health Network, Toronto, Ontario, Canada are interviewed about their work on novel approaches to radiosensitize cells.Our conversation is based on their article published in the June issue of Radiation Research: Gold Nanoparticles as Radiation Sensitizers in Cancer Therapy.

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How Do Mitochondrial Mutant Cells Respond to Radiation?

Posted By Administration, Friday, June 11, 2010
Updated: Monday, April 22, 2013

This months "News Minute with Vered” focuses on the odd story of the classification of the tomato as a vegetable.

Drs. Rohan Kulkarni and James Tucker are interviewed about their work on the response of mitochondrial mutant cells to genotoxic stresses such as ionizing radiation.Our conversation is based on their article published in the May issue of Radiation Research: Mitochondrial Gene Expression Changes in Normal and Mitochondrial Mutant Cells after Exposure to Ionizing Radiation.

Tags:  mitochondria  radiation damage 

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Microvessel Damage

Posted By Administration, Thursday, June 10, 2010
Updated: Monday, April 22, 2013

This months "News Minute with Vered” covers up the story of the origin of the Lab coat, and its colour.

Dr. Xiao Wen Mao was interviewed about their work on the response of micro vessels in the hippocampus after high-LET radiation.The conversation is based on their article published in the April issue of Radiation Research: High-LET radiation-induced response of microvessels in the Hippocampus.

 

Authors of this month’s article:
Xiao Wen Mao (pictured in the center), Cecile J. Favre (right), John R. Fike, Lucie Kubinova, Ella Anderson, Mary Campbell-Beachler, Tamako Jones, Anna Smith, Steven Rightnar, and Gregory A. Nelson (pictured left)

Tags:  High-LET 

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The Decreasing Dose Rate Effect

Posted By Administration, Friday, April 2, 2010
Updated: Monday, April 22, 2013

We begin our podcast with a "News Minute with Vered”, who discusses the nominees for the Nobel Peace prize for 2010. Will we win this year? This month our interview is with Karl Brehwens and Andrzej Wojcik and discusses their article: Cytogenetic Damage in Cells Exposed to Ionizing Radiation under Conditions of a Changing Dose Rate. The authors used a setup in which cells, kept at a constant temperature, moved to and from an X-ray source to expose them to a changing dose rate, as shown in their video: Experimental setup of Karl Brehwens and colleagues.

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An Adoptive Transfer Method to Detect Low-Dose Radiation-Induced Bystander Effects in Vivo

Posted By Administration, Tuesday, March 16, 2010
Updated: Monday, April 22, 2013
This months "News Minute with Vered” briefly reviews the recently published book "The Immortal Life of Henrietta Lacks” by Rebecca Skloot. Henrietta Lacks is the donor of the cells that became the original immortal cell line that most of us know as HeLa cells. Our interview of the month is with Dr. Benjamin Blyth and Prof. Pamela Sykes on their recently published article discussing a method to detect bystander effects in vivo induced by low dose radiation.

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Late Residual DNA Damage Margers In Vivo

Posted By Administration, Friday, February 26, 2010
Updated: Monday, April 22, 2013

Our interview of the month is with Robert Bristow, in which we discuss his recent work which appeared in the January issue of the Journal. The paper isentitled Late Residual γ-H2AX Foci In Murine Skin are Dose Responsive and Predict Radiosensitivity In Vivo no access

Any comments as to the content of the interview are encouraged.

Tags:  Biomarkers  DNA damage  radiation accident 

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Mitochondrial Dysfunction and Genomic Instability: Chicken or Egg?

Posted By Administration, Thursday, December 24, 2009
Updated: Monday, April 22, 2013

Welcome to the December issue of the Radiation Research Podcast. In this issue, Vered’s News Minute introduces our new jingles, written and performed b ySolarpunch.

Our interview of the month is to Disha Dayal (pictured on the left) and Douglas Spitz (pictured on the right), to discuss about their recent work appeared in the December issue of the Journal, of which they are first and last authors, respectively. The paper is entitled Mitochondrial Complex II Dysfunction Can Contribute Significantly to Genomic Instability after Exposure to Ionizing Radiation.

Any comments to the content of the interview are encouraged.

Happy festive season to all our listeners!

Tags:  genomic instability  oxidative stress 

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The Potentials of Tumor Oximetry and Cell Cycle Checkpoint Inhibition

Posted By Administration, Monday, December 14, 2009
Updated: Monday, April 22, 2013

Welcome to the November issue of the Radiation Research podcast!

In this issue, Vered’s News Minutefocuses on the risks of radiation exposure from multiple X-ray imaging tests.

The interview of the month is with Drs. Khan and Eastman from The Dartmouth Medical School and the Dartmouth-Hitchcock Medical Center in New Hampshire, describing the potentials of tumor pO2 measurements and the use of cell cycle checkpoint inhibitors in cancer treatment. This discussion is based on their article that appeared in the November issue of Radiation Research: Radiotherapy in Conjunction with 7-Hydroxystaurosporine: A Multimodal Approach with Tumor pO2 as a Potential Marker of Therapeutic Response

Tags:  tumor radiosensitization 

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