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Debate: Sunday, September 21, 2014

D1: Is the Abscopal (out-of-field) Effect Important to Curing Cancer with Radiation Therapy?

Silvia Formenti

Simon Powell

D2: Are There Viable Mitigators of Radiation Effects?

William McBride

Mark DeWhirst


Garry R. Buettner, PhD: PLENARY SPEAKER
Dr. Buettner is a Professor in the Free Radical and Radiation Biology Program/Department of Radiation Oncology at The University of Iowa. His research focuses on the flow of electrons through chemical, biochemical, and biological systems and the consequences of changing the current in different biological circuits.  In mitochondria electrons flow through a high flux circuit efficiently producing ATP, and H2O (respiration). However, some electrons do not flow to dioxygen, rather just to NAD+ (glycolysis).  Of special interest is the flow of electrons into the many low flux biochemical circuits that partially reduce dioxygen producing superoxide and hydrogen peroxide.  Understanding quantitatively the elements of these circuits (e.g. antioxidants, redox enzymes, and proteins) and how they dictate the fundamental biology of cells and tissues and overall health of organisms is the primary goal.  Using this information to improve human health is the ultimate reward.   

Nicholas Dainiak, M.D., F.A.C.P. is a graduate of Fairfield University and Loyola-Stritch School of Medicine.  He trained in Internal Medicine at Albany Medical Center and in Hematology at Yale University School of Medicine.  He rose to the rank of Professor of Medicine at Tufts University, and became Scientific Director of the Stem Cell Transplant Program and then Director of the Connecticut Cancer Institute at the University of Connecticut Health Center.  He was recruited to McGill as the Louis Lowenstein Chair of Hematology/Oncology and Chief of Hematology/Oncology at the Royal Victoria Hospital, Montreal.  He returned to Connecticut in 1995 where he served as Chairman of Medicine for 18 years at Yale New Haven Health–Bridgeport Hospital.  He is Clinical Professor of Internal Medicine and of Therapeutic Radiology (pending) at Yale. READ MORE...

Marco Durante, PhD
Marco Durante was appointed as the Director of the Biophysics Department at GSI Helmholtz Center (Darmstadt, Germany) in October 2008 and is now also Full Professor at the Technical University of Darmstadt (Germany) and Adjunct Professor at the Temple University, Philadelphia (PA, USA), the Frankfurt Institute for Advanced Studies (FIAS, Germany), and at the Gunma College of Medicine (Japan). He previously served as Associate Professor of Physics at the University of Naples Federico II (Italy). READ MORE...

Kenneth Kinzler, PhD

Kenneth Kinzler, Ph.D., is Professor of Oncology at The Sidney Kimmel Comprehensive Cancer Center (SKCCC) at the Johns Hopkins University School of Medicine is co-director of the Ludwig Center at Johns Hopkins University..  He has produced classic studies of the genes causing human cancer including the discovery of APC, the gene that initiates virtually all colorectal tumors.  His subsequent analyses of the functional properties of the APC gene product have had widespread ramifications for developmental biology as well as cancer biology.  He is also known for his development of genetic methods for analyzing gene expression and mutations in human cancer leading to his most recent work on defining the cancer genome for more than a dozen human tumor types.  He has coauthored over 350 peer-reviewed articles on the molecular analyses of cancer.


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