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Early Career Investigator (ECI)
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The Mission of the ECI Committee:

The Early Career Investigator (ECI) Committee, established in 2016, has been formally incorporated to the RRS Society. RRS wants to connect ECIs with each other as well as mentors of the Society, hear their experiences, and encourage their research programs.


Qualifications For ECI Membership Acceptance:
In order to apply you must be a Full or Sponsored Faculty Member of RRS in good standing. Submit your application for review by clicking on the link below:
CLICK HERE FOR APPLICATION




Early Career Investigator of the Month


Scott Welford, PhD
Associate Professor of Radiation Oncology, University of Miami

Dr. Welford's laboratory investigates mechanisms of radiation responses in cancer cells, the effect of hypoxia on cancer metabolism and signaling, and space radiobiology as it impacts radiation induced carcinogenesis. The lab is interested in brain and renal cancer models, taking advantage of similarities in their poor responses to therapy and hypoxic phenotypes. His overall goal is to identify novel therapeutic pathways and targets.


Dr. Welford has expertise in molecular biology, radiation oncology, and animal models of cancer, and focuses his research efforts towards developing novel strategies to combat cancer. Scott completed his doctoral studies at the Molecular Biology Institute of UCLA, under the supervision of Dr. Chris Denny, where his work investigated the molecular mechanisms of the chimeric transcription factors associated with Ewing’s Sarcoma. Ewing’s Sarcoma is genetically defined by recurrent chromosomal translocations that produce chimeric transcription factors. The fusion of principally an RNA binding protein (EWS) to the DNA binding domains of one of three predominant ETS transcription factors (FLI1, ERG, or ETV1) results in the aberrant expression of cohorts of target genes. A major question in the Ewing’s field was to define relevant target genes with altered expression to gain insight into how EWS/ETS fusions could drive tumorigenesis. Through the progress of this PhD work, Scott developed novel and highly impactful technologies to integrate microarray based transcriptional profiling with subtractive hybridization techniques, and elucidated mechanisms at work in Ewing’s Sarcoma.

Subsequently, Dr. Welford joined the laboratory of Dr. Amato Giaccia in the Department of Radiation Oncology at Stanford University for post-doctoral studies. The primary focus while at Stanford was in understanding the how aspects of tissue microenvironments contribute to tumor development and evolution. Hypoxia is a characteristic of nearly all solid tumors, developing as a result of limited blood supply to tumors and improper and inefficient angiogenesis. Scott’s studies were among the first to investigate the effects normal tissue oxygenation, which can range to levels that are quite low, on the transformation potential of common oncogenes. He showed that hypoxia, through HIF1, drives expression of a secreted cytokine (MIF) that could suppress the senescent effects of oxidative stress, arguing that in vivo oxygenation can serve as a protected niche for the early steps of cellular transformation. In kidney cancer, the defining genetic alteration is inactivation of the VHL tumor suppressor. Others had shown that loss of VHL could induce senescence in vitro. Scott then went on to demonstrate that oxygenation found in the kidney cortex could suppress VHL-loss induced senescence in vitro and in vivo, providing a possible explanation for the tissue specificity of VHL associated tumors. Together, the studies provided background for the current hypothesis that hypoxic niches serve as protective environments in tissues for cells that can reconstitute tumors.

Dr. Welford then moved to be independent investigator in Radiation Oncology first at Case Western Reserve University, and then at the University of Miami, where his projects utilize basic tissue culture models, animal tumor models, and clinical trial samples to more clearly define unique aspects of tumor cells that can be used for therapeutic intervention. During this time, the research interests have expanded to microenvironmental adaptations that promote resistance to ionizing radiation, and the effects of simulated space radiation on animal models. Together, the efforts support his overarching goals of identifying tumor determinants of therapeutic resistance, and devising strategies for sensitization.

 


 

Who Are Your ECI Mentors? Contact your mentor by clicking on the photo to email.




Chiara La Tessa, PhD
Biology, Medicine,
Physics/BioPhysics
Jan Schuemann, PhD
Physics/ Biophysics
Charles Maitz,
DVM, PhD, DACVR-RO
Biology, Chemistry,
Medicine
Nicole Simone, PhD
Biology, Medicine
       



 
Jeffrey Willey, PhD
Biology
David Yu, MD, PhD
Biology
Janice Zawaski, PhD
Biology
 

 

CME and Travel Awards Available for the Annual Meeting. More information coming soon!

Have additional questions about ECI membership? Contact Chiara La Tessa at chiara.latessa@unitn.it.



ECI Travel Award Archive:
2019
2018
2017
2016

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